Use of t2c001 in cardiac diseaseAnwendung von t2c001 bei Herzerkrankungen
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    Use of t2c001 in cardiac disease

    The following scientific articles have been published on the use of t2c001 and other cell therapies developed by different research groups: 

    Assmus B, Rolf A, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Tillmanns H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Tonn T, Dimmeler S, Dill T, Zeiher AM, and Schächinger V (2010). Clinical Outcome 2 Years After Intracoronary Administration of Bone Marrow-Derived Progenitor Cells in Acute Myocardial Infarction. Circulation Heart Failure;3:89-96

    Dill T, Schächinger V, Rolf A, Möllmann S, Thiele H, Tillmanns H, Assmus B, Dimmeler S, Zeiher AM, Hamm C (2009). Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: Results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac Magnetic Resonsance Imaging substudy. Am Heart J 157:541-7       

    Fischer-Rasokat U, Assmus B, Seeger FH, Honold J, Leistner D, Fichtlscherer S, Schächinger V, Tonn T, Martin H, Dimmeler S, Zeiher AM (2009): A pilot trial to assess potential effects of selective intracoronary bone marrow-derived progenitor cell infusion in patients with nonischemic dilated cardiomyopathy: final 1-year results of the transplantation of progenitor cells and functional regeneration enhancement pilot trial in patients with nonischemic dilated cardiomyopathy. Circ Heart Fail. Sep;2(5):417-23.

    Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, Wen Y, Rapp JA, Kessler J. (2008): Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. JAMA. 299(8):925-36. 

    Erbs S, Linke A, Schächinger V, Assmus B, Thiele H, Diederich KW, Hoffmann C, Dimmeler S, Tonn T, Hambrecht R, Zeiher AM, Schuler G. (2007): Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation. 116(4):366-74. 

    Assmus B, Fischer-Rasokat U, Honold J, Seeger FH, Fichtlscherer S, Tonn T, Seifried E, Schächinger V, Dimmeler S, Zeiher AM (2007): Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry. Circ Res.;100(8):1234-41 

    Lipinski MJ, Biondi-Zoccai GG, Abbate A, Khianey R, Sheiban I, Bartunek J, Vanderheyden M, Kim HS, Kang HJ, Strauer BE, Vetrovec GW (2007): Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 50(18):1761-7 

    Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B. (2007): Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med.;167(10):989-97 

    Schächinger V., S. Erbs, A. Elsässer, W. Haberbosch, M. Hambrecht, H. Hölschermann, J. Yu, R. Corti, D.G. Mathey, C.W. Hamm, T. Süselbeck, B. Assmus, T. Tonn, S. Dimmeler, A.M. Zeiher (2006): Intracoronary Bone Marrow-Derived Progentor Cells in Acute Mycardial Infaction. N. Engl. J. Med. , 355, 1210-1221. 

    Schächinger V., S. Erbs, A. Elsässer, W. Haberbosch, R. Hambrecht, H. Hölschermann, J. Yu, R. Corti, D.G. Mathey, C.W. Hamm, T. Süselbeck, N. Werner, J. Haase, J. Neuzner, A. Germing, B. Mark, B. Assmus, T. Tonn, S. Dimmler, A.M. Zeiher (2006). Improved clinical outcome after intracoronary administration of bone-marrow.derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur. Heart J., 27, 2775-2783. 

    Assmus B, J. Honold, M.B. Britten, U. Fischer-Rasokat, R. Lehmann, C. Teupe, K. Pistorius, H. Martin, N.D. Abolmaali, T. Tonn, S. Dimmeler, A.M. Zeiher (2006): Transcoronary Transplantation of Progenitor Cells after Myocardial Infarction. N. Engl. J. Med, 355, 1222-1232. 

    Bartunek J, M. Vanderheyden, B. Vanderkerckhove, S. Mansour, B. De Bruyne, P. De Bondt, I. Van Haute, N. Lootens, G. Heyndrickx, W. Wijns. (2005): Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promote cardiac recovery after recent myocardial infarction. Circulation, 112 (Suppl I), I178-I183. 

    Schächinger V., B. Assmus, M.B. Britten, J. Honold, R. Lehmann, C. Teupe, N.D. Nasreddin, T.J. Vogl, W.-K. Hofmann, H. Martin, S. Dimmeler, A.M. Zeiher. (2004): Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction. J. Am. Coll. Cardiol. 44, 1690-1699. 

    Wollert K.C., G.P. Meyer, J. Lotz, S. Ringes-Lichtenberg, P. Lippolt, C. Breidenbach, S. Fichtner, T. Korte, B. Hornig, D. Messinger, L. Arseniev, B. Hertenstein, A. Ganser, H. Drexler. (2004): Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet, 364, 141-148. 

    Britten M.B., N. Abomaali, B. Assmus, R. Lehmann, J. Honold, J. Schmitt, T.J. Vogl, H. Martin, V. Schächinger, S. Dimmeler, A.M. Zeiher (2003): Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI). Circulation, 108, 2212-2218. 

    Assmus B, V. Schächinger, C. Teupe, M. Britten, R. Lehmann, N. Döbert, F. Grünwald, A. Aicher, C. Urbich, H. Martin, D. Hoelzer, S. Dimmeler, A.M. Zeiher (2002): Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation; 106: 3009-3017. 

    Strauer B.E., M. Brehm, T. Zeus, N. Gattermann, A. Hernandez, R.V. Sorg, G. Kögler, P. Wernet. (2001): Intracoronare, humane autologe Stammzelltransplantation zur Myokardregeneration nach Herzinfarkt. Dtsch. med. Wschr., 126, 932-938. 

    Dill T, Schächinger V, Rolf A, Möllmann S, Thiele H, Tillmanns H, Assmus B, Dimmeler S, Zeiher AM, Hamm C (2009). Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy. Am Heart J. Mar; 157(3):541-7.