t2cure’s cell therapy is available through cooperating clinical centres
    t2cure cooperates with experienced partners in research and in the industry.
    t2cure's pipeline is built on clinical studies in cardiac and peripheral vascular indications
    t2cure is dedicated to the development of novel progenitor cell-based regenerative therapeutics.


    Adult stem cells and progenitor cells

    Stem cells and progenitor cells that are obtained from an adult individual. Sources of such adult cells are for instance bone marrow or blood. They are also found in other organ tissues. In skin for example they have an important role in scar formation after wounding. Adult stem cells from bone marrow are responsible for the continuous formation of new blood cells. Therapies using autologous adult stem cells bear no risk of rejection inside the body and are considered free of ethical issues.


    An increase in the diameter of existing arterial vessels.


    Donor and recipient are identical. This means that for an autologous cellular product the patient gets back cells that originate from his own cells and not from a foreign donor.


    Bone Marrow Cell

    Chronic ischemic heart disease

    Disease characterized by reduced blood supply to the heart muscle, usually due to atherosclerosis of the coronary arteries.

    Dilated cardiomyopathy

    A condition in which the heart becomes weakened and enlarged, and cannot pump blood efficiently.


    The tissue covering the inner surface of blood vessels.


    Separation of cells by different density levels.


    Good Manufacturing Practice


    Ischemic means that a tissue is insufficiently supplied with blood and thus suffering from too litle oxygen and nutrients.

    Mesenchymal stem cells

    Type of cells that can form several tissues in the body, including bone, cartilage, muscles, blood vessels, connective or fatty tissue.


    The frequency of a disease in a segment of the population.


    Death rate.

    Multipotent stem cell

    Cell carrying the potency of changing itself into different cell types.


    Cardiac muscle


    Neovascularization is the formation of new capillaries and blood vessels to supply ischemic tissue.


    This means that a cell produces and excretes certain factors that have an effect on immediate neighbour cells.

    Peripheral artery occlusive disease

    Disease caused by obstruction of large arteries in legs and arms.


    Outer part of the body

    Progenitor cell

    Progenitor cells are cells with somewhat limited stem cell properties. E.g., they can only differentiate into certain tissue types. In colloquial language, progenitor cells are often referred to as "stem cells".


    Restoration of blood flow in a blood vessel where blood flow had been obstructed due to narrowing or closure.

    Stem cell

    Stem cells are non specialized cells with an unlimited capacity to self renewal and the capacity to differentiate into various cell types. Stem cells are a reservoir for the formation and renewal of organs and tissues.


    Thromboangiitis obliterans

    Rare inflammatory peripheral vascular disease, also called Buerger's disease


    Formation of a blood clot (thrombus) inside a blood vessel, obstructing the flow of blood through the circulatory system.


    Transdifferentiation means that a progenitor cell that is already committed to a certain cell type changes its properties and characteristics to those of another cell type. For instance the changes from a blood renewing progenitor cell into a heart muscle cell would be referred to as transdifferentiation. Experimentally, many forms of transdifferentiation have been described. It is however unclear to what extent this phenomenon is of relevance in regenerating damaged cardiac tissue.


    Ventricle means heart chamber.